TargetMol

JAK2/FLT3-IN-1

Product Code:
 
TAR-T11707
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11707-5mg5mg£571.00
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TAR-T11707-50mg50mg£1,661.00
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Quantity:
TAR-T11707-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
JAK2/FLT3-IN-1 has anti-cancer activity. JAK2/FLT3-IN-1 is a potent and orally effective dual JAK2/FLT3 (Janus kinase 2/ FMS-like tyrosine kinase 3) inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively.
CAS:
2387765-27-5
Formula:
C25H34FN7O
Molecular Weight:
467.593
Pathway:
MAPK
Purity:
0.98
SMILES:
CC(C)n1cc(cn1)-c1nc(Nc2ccc(N3CCC(CC3)N(C)CCO)c(F)c2)ncc1C
Target:
JNK

References

1. Yang T, et al. Discovery of Potent and Orally Effective Dual JAK2/FLT3 Inhibitors for the Treatment of AcuteMyelogenous Leukemia and Myeloproliferative Neoplasms. J Med Chem. 2019 Oct 31.