TargetMol

JAK3 covalent inhibitor-1

Product Code:
 
TAR-T11709
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11709-5mg5mg£1,492.00
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Quantity:
TAR-T11709-50mg50mg£2,946.00
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Quantity:
TAR-T11709-100mg100mg£4,006.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs.
CAS:
2300106-50-5
Formula:
C22H17FN6O2S
Molecular Weight:
448.48
Pathway:
Angiogenesis; Chromatin/Epigenetic; Stem Cells; JAK/STAT signaling
Purity:
0.98
SMILES:
Fc1cccc(c1)S(=O)(=O)N[C@@H]1C[C@H](NC#N)c2cc(ccc12)-c1ncnc2[nH]ccc12
Target:
JAK

References

1. Casimiro-Garcia A, et al. Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. J Med Chem. 2018 Dec 13;61(23):10665-10699.