TargetMol

JTV-519 free base

Product Code:
 
TAR-T11731
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11731-5mg5mg£850.00
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Quantity:
TAR-T11731-50mg50mg£1,661.00
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Quantity:
TAR-T11731-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
JTV-519 free base (K201 free base),Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle.
CAS:
145903-06-6
Formula:
C25H32N2O2S
Molecular Weight:
424.6
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
COc1ccc2SCCN(Cc2c1)C(=O)CCN1CCC(Cc2ccccc2)CC1
Target:
FLT

References

1. Darcy YL, et al. K201 (JTV519) is a Ca 2. Kaneko N, et al. Inhibition of annexin V-dependent Ca2+ movement in large unilamellar vesicles by K201, a new 1,4-benzothiazepine derivative. Biochim Biophys Acta. 1997 Nov 13;1330(1):1-7. 3. Yang J, et al. Toll-like receptor 4-induced ryanodine receptor 2 oxidation and sarcoplasmic reticulum Ca