TargetMol

MBM-17S

Product Code:
 
TAR-T11959
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11959-5mg5mg£930.00
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TAR-T11959-50mg50mg£1,821.00
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TAR-T11959-100mg100mg£2,319.00
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Further Information

Bioactivity:
MBM-17S effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-17S shows antitumor activities, and no obvious toxicity to mice.MBM-17S is a potent NIMA-related kinase 2 (Nek2) inhibitor, with an IC50 of 3 nM.
CAS:
2083621-91-2
Formula:
C36H40N6O10
Molecular Weight:
716.748
Pathway:
Cell Cycle/Checkpoint; Chromatin/Epigenetic
Purity:
0.98
SMILES:
OC(=O)CCC(O)=O.OC(=O)CCC(O)=O.CN(C)CCn1cc(cn1)-c1ccn2c(cnc2c1)-c1ccc(C(N)=O)c(OCc2ccccc2)c1
Target:
Aurora Kinase

References

1. Xi JB, et al. Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem. 2017 Jan 27;126:1083-1106.