TargetMol

MI-1061

Product Code:
 
TAR-T12031
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12031-5mg5mg£304.00
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TAR-T12031-50mg50mg£1,267.00
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Quantity:
TAR-T12031-100mg100mg£1,966.00
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This product comes from: United States.
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Further Information

Bioactivity:
MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).
CAS:
1410737-34-6
Formula:
C30H26Cl2FN3O4
Molecular Weight:
582.45
Pathway:
Apoptosis
Purity:
0.98
SMILES:
OC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@]3([C@H]2c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc32)cc1
Target:
Mdm2

References

1. Aguilar A, et al. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannichring-opening-cyclization reaction mechanism in spiro-oxindoles. J Med Chem. 2014 Dec 26;57(24):10486-98.