TargetMol

NB-598 hydrochloride

Product Code:
 
TAR-T12199L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T12199L-5mg5mg£850.00
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TAR-T12199L-50mg50mg£1,661.00
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Quantity:
TAR-T12199L-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
NB-598 hydrochloride is a competitive squalene epoxidase (SE) inhibitor.
CAS:
136719-25-0
Formula:
C27H32ClNOS2
Molecular Weight:
486.13
Pathway:
Microbiology/Virology
Purity:
0.98
SMILES:
Cl.CCN(CC=CC#CC(C)(C)C)Cc1cccc(OCc2cc(cs2)-c2ccsc2)c1
Target:
Antifungal

References

1. Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45. 2. Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305. 3. Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51.