TargetMol

NF546

Product Code:
 
TAR-T12217
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12217-5mg5mg£850.00
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Further Information

Bioactivity:
NF546 is a selective agonist of non-nucleotide P2Y11(pEC50 of 6.27).
CAS:
1006028-37-0
Formula:
C47H44N6Na4O17P4
Molecular Weight:
1180.748
Purity:
0.98
SMILES:
Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(CP(O)(=O)O[Na])cc2CP(O)(=O)O[Na])c1)C(=O)Nc1ccc(CP(O)(=O)O[Na])cc1CP(O)(=O)O[Na]

References

1. Meis S, et al. NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells. J Pharmacol Exp Ther. 2010 Jan;332(1):238-47.