TargetMol

Norverapamil

Product Code:
 
TAR-T12244
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12244-5mg5mg£850.00
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TAR-T12244-50mg50mg£1,661.00
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Quantity:
TAR-T12244-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Norverapamil is a blocker of L-type calcium channel and an inhibitor of P-glycoprotein (P-gp) function .
CAS:
67018-85-3
Formula:
C26H36N2O4
Molecular Weight:
440.584
Pathway:
Metabolism; Membrane transporter/Ion channel
Purity:
0.98
SMILES:
COc1ccc(CCNCCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
Target:
Calcium Channel

References

1. Adams KN, et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210(3):456-66. 2. Choi DH, et al. Effects of simvastatin on the pharmacokinetics of verapamil and its main metabolite, norverapamil, in rats. Eur J Drug Metab Pharmacokinet. 2009 Jul-Sep;34(3-4):163-8. 3. Wang J et al. A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human. Eur J Pharm Sci. 2013 Nov 20;50(3-4):290-302.