TargetMol

R 80123

Product Code:
 
TAR-T12611
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
R 80123 is a highly selective inhibitor of phosphodiesterase,is the Z-isomer of R 79595
CAS:
133718-30-6
Formula:
C26H29N5O3
Molecular Weight:
459.55
Purity:
0.98
SMILES:
CN(C1CCCCC1)C(=O)CON=C(c1ccccc1)c1ccc2N=C3NC(=O)CN3Cc2c1

References

1. Vandeplassche GM et al. Comparative effects of R 80122, enoximone, and milrinone on left ventricular phosphodiesterase isoenzymes in vitro and on contractility of normal and stunned myocardium in vivo in dogs. J Cardiovasc Pharmacol. 1992 May;19(5):714-22. https://www.ncbi.nlm.nih.gov/pubmed/ 1381769 2. Schneider J et al. Cardiac effects of R 79595 and its isomers (R 80122 and R 80123) in an acute heart failure model. A new class of cardiotonic agents with highly selective phosphodiesterase III inhibitory properties. Naunyn Schmiedebergs Arch Pharmacol. 1992 Nov;346(5):563-72. 3. Vandeplassche GM et al. Comparative effects of R 80122, enoximone, and milrinone on left ventricular phosphodiesterase isoenzymes in vitro and on contractility of normal and stunned myocardium in vivo in dogs. J Cardiovasc Pharmacol. 1992 May;19(5):714-22.