TargetMol

CE3F4

Product Code:
 
TAR-T12616L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T12616L-5mg5mg£108.00
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TAR-T12616L-1mL1 mL * 10 mM (in DMSO)£112.00
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TAR-T12616L-10mg10mg£135.00
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TAR-T12616L-25mg25mg£196.00
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Quantity:
TAR-T12616L-50mg50mg£302.00
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Further Information

Bioactivity:
CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac1; IC50s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively).
CAS:
143703-25-7
Formula:
C11H10Br2FNO
Molecular Weight:
351.013
Pathway:
GPCR/G Protein
Purity:
0.9715
SMILES:
CC1CCc2c(Br)c(F)c(Br)cc2N1C=O
Target:
cAMP

References

1. Courilleau D, et al. The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem Biophys Res Commun. 2013 Oct 25;440(3):443-8. 2. Courilleau D, et al. Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. J Biol Chem. 2012 Dec 28;287(53):44192-202. 3. Pratt EP, et al. Ca2+ influx through L-type Ca2+ channels and Ca2+-induced Ca2+ release regulate cAMP accumulation and Epac1-dependent ERK 1/2 activation in INS-1 cells. Mol Cell Endocrinol. 2016 Jan 5;419:60-71.