TargetMol

(R)-(-)- α-Methylhistamine dihydrobromide

Product Code:
 
TAR-T12630
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12630-5mg5mg£850.00
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TAR-T12630-50mg50mg£1,661.00
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Quantity:
TAR-T12630-100mg100mg£2,079.00
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Further Information

Bioactivity:
(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective agonist of H3 histamine receptor( Kd of 50.3 nM).
CAS:
868698-49-1
Formula:
C6H13Br2N3
Molecular Weight:
286.999
Pathway:
Neuroscience; Immunology/Inflammation; GPCR/G Protein
Purity:
0.98
SMILES:
Br.Br.C[C@@H](N)Cc1cnc[nH]1
Target:
Histamine Receptor

References

1. Mohammad Shahid, et al. Histamine, Histamine Receptors, and their Role in Immunomodulation: An Updated Systematic Review. The Open Immunology Journal, 2009, 2, 9-41. 2. Oishi R, et al. Effects of the histamine H3-agonist (R)-alpha-methylhistamine and the antagonist thioperamideon histamine metabolism in the mouse and rat brain. J Neurochem. 1989 May;52(5):1388-92. 3. Yamasaki S, et al. The disposition of (R)-alpha-methylhistamine, a histamine H3-receptor agonist, in rats. J Pharm Pharmacol. 1994 May;46(5):371-4. 4. Li WW, et al. (R)-alpha-methylhistamine suppresses inhibitory neurotransmission in hippocampal CA1 pyramidal neurons counteracting propofol-induced amnesia in rats. CNS Neurosci Ther. 2014 Sep;20(9):851-9.