TargetMol

(R)-(+)-Anatabine

Product Code:
 
TAR-T12636
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12636-5mg5mg£850.00
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Further Information

Bioactivity:
(R)-(+)-Anatabine is an less active R-enantiomer of Anatabine. Anatabine is a potent agonist of α4β2 nAChR.
CAS:
126454-22-6
Formula:
C10H12N2
Molecular Weight:
160.22
Purity:
0.98
SMILES:
C1N[C@H](CC=C1)c1cccnc1

References

1. Jothi L. Nallasivam, et al. Synthetic modifications of bifunctional homoallylamines: Synthesis of 2-arylpiperidines, (R)-anatabine and (R)-anabasine. An International Journal for Rapid Communication of Synthetic Organic Chemistry. Volume 49, 2019-Issue 21: 2815-2822. 2. Paris D, et al. Anatabine lowers Alzheimer's A? production in vitro and in vivo. Eur J Pharmacol. 2011 Nov 30;670(2-3):384-91. 3. Xing H, et al. A Pharmacological Comparison of Two Isomeric Nicotinic Receptor Agonists: The Marine Toxin Isoanatabine and the Tobacco Alkaloid Anatabine. Mar Drugs. 2020 Feb 11;18(2). pii: E106. 4. eo EJ, et al. Phytochemicals as inhibitors of NF-?B for treatment of Alzheimer's disease. Pharmacol Res. 2018 Mar;129:262-273.