TargetMol

RU-SKI 43

Product Code:
 
TAR-T12797
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12797-1mg1mg£107.00
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TAR-T12797-5mg5mg£159.00
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TAR-T12797-1mL1 mL * 10 mM (in DMSO)£165.00
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TAR-T12797-10mg10mg£197.00
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TAR-T12797-25mg25mg£372.00
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TAR-T12797-50mg50mg£518.00
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This product comes from: United States.
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Further Information

Bioactivity:
RU-SKI 43 is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat) (IC50 of 850 nM), has anti-cancer activity.
CAS:
1043797-53-0
Formula:
C22H30N2O2S
Molecular Weight:
386.55
Pathway:
Metabolism|GPCR/G Protein|Stem Cells
Purity:
0.98
SMILES:
CCC(C)CNCC(=O)N1CCc2sccc2C1COc1cccc(C)c1
Target:
Hedgehog/Smoothened|Acyltransferase

References

1. Petrova E, et al. Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.Nat Chem Biol. 2013 Apr;9(4):247-9. 2. Petrova E, et al. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. 2014 Jan 27. doi: 10.1038/onc.2013.575.