TargetMol

S-methyl DM1

Product Code:
 
TAR-T12805
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12805-5mg5mg£570.00
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TAR-T12805-50mg50mg£1,821.00
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Quantity:
TAR-T12805-100mg100mg£2,319.00
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This product comes from: United States.
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Further Information

Bioactivity:
S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 μM) and inhibts microtubule polymerization.
CAS:
912569-84-7
Formula:
C36H50ClN3O10S
Molecular Weight:
752.32
Pathway:
Cytoskeletal Signaling
Purity:
0.98
SMILES:
[H][C@@]12C[C@@](O)(NC(=O)O1)[C@]([H])(OC)C=C/C=C(C)Cc1cc(OC)c(Cl)c(c1)N(C)C(=O)C[C@]([H])(OC(=O)[C@H](C)N(C)C(=O)CCSC)[C@]1(C)O[C@H]1[C@@H]2C
Target:
Microtubule Associated

References

1. Lopus M, et al. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther. 2010 Oct;9(10):2689-99. 2. Oroudjev E, et al. Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability. Mol Cancer Ther. 2010 Oct;9(10):2700-13.