TargetMol

TD-0212 TFA

Product Code:
 
TAR-T13125L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13125L-5mg5mg£870.00
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TAR-T13125L-50mg50mg£2,946.00
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Quantity:
TAR-T13125L-100mg100mg£4,006.00
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This product comes from: United States.
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Further Information

Bioactivity:
TD-0212 TFA is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).
CAS:
1073549-11-7
Formula:
C30H35F4N3O6S
Molecular Weight:
641.68
Purity:
0.98
SMILES:
OC(=O)C(F)(F)F.CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(cc1F)-c1ccccc1C(O)=O

References

1. McKinnell RM, et al. Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI). ACS Med Chem Lett. 2018 Dec 3;10(1):86-91.