TargetMol

Timegadine

Product Code:
 
TAR-T13160
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13160-5mg5mg£850.00
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TAR-T13160-50mg50mg£1,661.00
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Quantity:
TAR-T13160-100mg100mg£2,079.00
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Further Information

Bioactivity:
Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates and in washed rabbit platelets.
CAS:
71079-19-1
Formula:
C20H23N5S
Molecular Weight:
365.5
Pathway:
Immunology/Inflammation; Neuroscience
Purity:
0.98
SMILES:
Cc1cc(N=C(/NC2CCCCC2)Nc2nccs2)c2ccccc2n1
Target:
COX

References

1. George S, et al. The influence of food intake on the bioavailability of timegadine, a novel non-steroidal anti-inflammatory drug. Br J Clin Pharmacol. 1983 Apr;15(4):495-8. 2. Ahnfelt-R?nne I, et al. A new antiinflammatory compound, timegadine (N-cyclohexyl-N"-4-[2-methylquinolyl]-N'-2-thiazolylguanidine), which inhibits both prostaglandin and 12-hydroxyeicosatetraenoic acid (12-HETE) formation. Biochem Pharmacol. 1980 Dec;29(24):3265-9.