TargetMol

TRPA1 Antagonist 1

Product Code:
 
TAR-T13212
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13212-5mg5mg£1,813.00
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Quantity:
TAR-T13212-50mg50mg£3,589.00
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Quantity:
TAR-T13212-100mg100mg£4,970.00
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This product comes from: United States.
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Further Information

Bioactivity:
TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.
CAS:
1984825-08-2
Formula:
C24H20F6N5Na2O7PS
Molecular Weight:
713.46
Pathway:
Membrane transporter/Ion channel
Purity:
0.98
SMILES:
C[C@H]1[C@H](F)C[C@H](N1S(=O)(=O)c1ccc(F)cc1)C(=O)N(COP(=O)(O[Na])O[Na])Cc1cc(ncc1F)-c1cnc(nc1)C(F)(F)F
Target:
TRP/TRPV Channel

References

1. Chen H, et al. Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling. J Med Chem. 2018 Apr 26;61(8):3641-3659.