TargetMol

W146

Product Code:
 
TAR-T13327
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13327-5mg5mg£930.00
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TAR-T13327-50mg50mg£1,821.00
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Quantity:
TAR-T13327-100mg100mg£2,319.00
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This product comes from: United States.
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Further Information

Bioactivity:
W146 is a selective sphingosine-1-phosphate receptor 1 (S1PR1) antagonist (EC50: 398 nM).
CAS:
909725-61-7
Formula:
C16H27N2O4P
Molecular Weight:
342.376
Purity:
0.98
SMILES:
CCCCCCc1cccc(NC(=O)[C@H](N)CCP(O)(O)=O)c1

References

1. M Germana Sanna, et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2(8):434-41. Epub 2006 Jul 9. 2. Hang Wang, et al. Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway. Cell Biol Int. 2018 May 23. 3. Jingjing Liu, et al. 3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals. J Biochem Pharmacol Res. 2013 Dec; 1(4): 197?203.