TargetMol

AE0047 Hydrochloride

Product Code:
 
TAR-T13328
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13328-5mg5mg£850.00
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TAR-T13328-50mg50mg£1,661.00
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TAR-T13328-100mg100mg£2,079.00
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Further Information

Bioactivity:
AE0047 Hydrochloride is a blocker of calcium, and used in the research of the hypertensive disease.
CAS:
116308-56-6
Formula:
C41H43ClN4O6
Molecular Weight:
723.27
Pathway:
Membrane transporter/Ion channel; Metabolism
Purity:
0.98
SMILES:
Cl.COC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)N(=O)=O)C(=O)OCCc1ccc(cc1)N1CCN(CC1)C(c1ccccc1)c1ccccc1
Target:
Calcium Channel

References

1. Ashimori A, et al. Novel 1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive activity of 3-[4-(substituted amino)phenylalkyl]ester derivatives. Chem Pharm Bull (Tokyo). 1991 Jan;39(1):91-9. 2. Ashimori A, et al. Synthesis and pharmacological effects of optically active 2-[4-(4-benzhydryl-1-piperazinyl)phenyl]-ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride. Chem Pharm Bull (Tokyo). 1991 Jan;39(1):108-11. 3. Yamanaga K, et al. AE0047-mediated calcium channel blocking in vascular smooth muscles. Gen Pharmacol. 1997 Sep;29(3):337-43. 4. Nishikawa M, et al. Protection against endothelial abnormalities by a novel calcium channel blocker, AE0047, in stroke-prone spontaneously hypertensive rats. Gen Pharmacol. 1999 Mar;32(3):299-305.