TargetMol

YKL-5-124 TFA (1957203-01-8 free base)

Product Code:
 
TAR-T13367
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13367-100mg100mgEnquire
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TAR-T13367-50mg50mgEnquire
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TAR-T13367-5mg5mg£253.00
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TAR-T13367-1mL1 mL * 10 mM (in DMSO)£323.00
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TAR-T13367-10mg10mg£381.00
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Further Information

Bioactivity:
YKL-5-124 TFA is a potent, selective, irreversible and covalent inhibitor of CDK7 (IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively).
CAS:
T13367
Formula:
C30H34F3N7O5
Molecular Weight:
629.63
Purity:
0.98
SMILES:
CC1(C)N(C(N[C@@H](C2=CC=CC=C2)CN(C)C)=O)CC3=C1NN=C3NC(C4=CC=C(NC(C=C)=O)C=C4)=O.FC(F)(C(O)=O)F

References

1. Olson CM, et al. Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype. Cell Chem Biol. 2019 Jun 20;26(6):792-803.e10.