TargetMol

Talarozole (R enantiomer)

Product Code:
 
TAR-T13422L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T13422L-5mg5mg£850.00
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Quantity:
TAR-T13422L-50mg50mg£1,661.00
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Quantity:
TAR-T13422L-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid.
CAS:
870093-23-5
Formula:
C21H23N5S
Molecular Weight:
377.51
Purity:
0.98
SMILES:
CCC(CC)[C@H](c1ccc(Nc2nc3ccccc3s2)cc1)n1cncn1

References

1. Pavez Lori? E, Cools M, Borgers M, Topical treatment with CYP26 inhibitor talarozole (R115866) dose dependently alters the expression of retinoid-regulated genes in normal human epidermis. Br J Dermatol. 2009 Jan;160(1):26-36 2. Geria AN, Scheinfeld NS. Talarozole, a selective inhibitor of P450-mediated all-trans retinoic acid for the treatment of psoriasis and acne. Curr Opin Investig Drugs. 2008 Nov;9(11):1228-37. 3. Baert B, De Spiegeleer B. Local skin pharmacokinetics of talarozole, a new retinoic acid metabolism-blocking agent. Skin Pharmacol Physiol. 2011;24(3):151-9.