TargetMol

Demeclocycline

Product Code:
 
TAR-T1400L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T1400L-100mg100mgEnquire
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Further Information

Bioactivity:
Demeclocycline is a semi-synthetic tetracycline antibiotic from Streptomyces aureofaciens strain. Demeclocycline binds to the bacterial 30S ribosomal subunit and prevents aminoacyl-tRNA binding to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Demeclocycline can also inhibit the effect of vasopressin on the renal tubules, thereby causing diuresis.
CAS:
127-33-3
Formula:
C21H21ClN2O8
Molecular Weight:
464.86
Purity:
0.98
SMILES:
CN(C)[C@H]1[C@@H]2C[C@@H]3[C@H](O)c4c(Cl)ccc(O)c4C(O)=C3C(=O)[C@]2(O)C(O)=C(C(N)=O)C1=O

References

1. Miell J, Dhanjal P, Jamookeeah C. Evidence for the use of demeclocycline in the treatment of hyponatraemia secondary to SIADH: a systematic review. Int J Clin Pract. 2015 Dec;69(12):1396-417. doi: 10.1111/ijcp.12713. Epub 2015 Aug 19. Review. PubMed PMID: 26289137. 2. Wirth D, Smith TW, Moser R, Yaroslavsky AN. Demeclocycline as a contrast agent for detecting brain neoplasms using confocal microscopy. Phys Med Biol. 2015 Apr 7;60(7):3003-11. doi: 10.1088/0031-9155/60/7/3003. Epub 2015 Mar 19. PubMed PMID: 25790138. 3. Wirth D, Snuderl M, Curry W, Yaroslavsky A. Comparative evaluation of methylene blue and demeclocycline for enhancing optical contrast of gliomas in optical images. J Biomed Opt. 2014 Sep;19(9):90504. doi: 10.1117/1.JBO.19.9.090504. PubMed PMID: 25239672. 4. Kortenoeven ML, Sinke AP, Hadrup N, Trimpert C, Wetzels JF, Fenton RA, Deen PM. Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1705-18. doi: 10.1152/ajprenal.00723.2012. Epub 2013 Oct 23. PubMed PMID: 24154696.