TargetMol

A-935142

Product Code:
 
TAR-T14077
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14077-1mg1mg£352.00
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Quantity:
TAR-T14077-5mg5mg£736.00
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Quantity:
TAR-T14077-10mg10mg£978.00
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Quantity:
TAR-T14077-25mg25mg£1,348.00
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Quantity:
TAR-T14077-50mg50mg£1,661.00
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Quantity:
TAR-T14077-100mg100mg£2,079.00
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Quantity:
TAR-T14077-500mg500mg£4,006.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, slowing of deactivation, reduction of inactivation, and abbreviates atrial and ventricular repolarization[1][2].
CAS:
1031335-85-9
Formula:
C18H19F3N2O2
Molecular Weight:
352.357
Pathway:
Angiogenesis|Tyrosine Kinase/Adaptors|JAK/STAT signaling
Purity:
0.98
SMILES:
OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1cc([nH]n1)C(F)(F)F
Target:
EGFR

References

1. Ohno H, et al. Absorption, disposition, metabolism and excretion of [14C]mizagliflozin, a novel selective SGLT1 inhibitor, in rats. Xenobiotica. 2019 Apr;49(4):463-473. 2. Liu X, et al.Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers. Life Sci. 2012 Apr 20;90(15-16):607-11.