TargetMol

AZD2423

Product Code:
 
TAR-T14373
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14373-5mg5mg£1,091.00
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TAR-T14373-50mg50mg£2,143.00
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Quantity:
TAR-T14373-100mg100mg£2,801.00
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This product comes from: United States.
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Further Information

Bioactivity:
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for CCR2 Ca2+ flux [1][2][3].
CAS:
1229603-37-5
Formula:
C20H29ClFN5O2
Molecular Weight:
425.93
Pathway:
Immunology/Inflammation; Microbiology/Virology
Purity:
0.98
SMILES:
CC(C)(C)N1CCN[C@H](C1)C(=O)N1CCN(CC1)C(=O)Nc1ccc(Cl)c(F)c1
Target:
CCR

References

1. AZD2423. 2. John G. Cumming. CCR2 antagonists for the treatment of neuropathic pain: The discovery and development of AZD2423. 3. Kalliom?ki J, et al. A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia. Pain. 2013 May;154(5):761-7.