TargetMol

BETd-260

Product Code:
 
TAR-T14550
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14550-50mg50mgEnquire
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TAR-T14550-1mg1mg£241.00
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TAR-T14550-5mg5mg£390.00
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TAR-T14550-10mg10mg£546.00
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TAR-T14550-25mg25mg£831.00
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This product comes from: United States.
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Further Information

Bioactivity:
BETd-260 is a potent degrader of BET based on PROTAC technology, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line.
CAS:
2093388-62-4
Formula:
C43H46N10O6
Molecular Weight:
798.905
Pathway:
; Chromatin/Epigenetic
Purity:
0.98
SMILES:
CCn1nc(cc1Nc1nc(nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12)C(=O)NCCCCCc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O)C1CC1
Target:
Epigenetic Reader Domain

References

1. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.