TargetMol

BMS-066

Product Code:
 
TAR-T14669
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14669-5mg5mg£1,332.00
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TAR-T14669-50mg50mg£2,625.00
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TAR-T14669-100mg100mg£3,524.00
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This product comes from: United States.
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Further Information

Bioactivity:
BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.
CAS:
914946-88-6
Formula:
C19H21N7O2
Molecular Weight:
379.424
Pathway:
NF-κb; Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
CNc1nc2[nH]c(cc2c2n(C)cnc12)-c1cccc(CNC(=O)COC)n1
Target:
IκB/IKK; Tyrosine Kinases

References

1. Gillooly KM, et al. Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis. J Pharmacol Exp Ther. 2009 Nov;331(2):349-60. 2. Tokarski JS, et al. Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain. J Biol Chem. 2015 Apr 24;290(17):11061-74.