TargetMol

Edotecarin

Product Code:
 
TAR-T15200
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15200-5mg5mg£1,251.00
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TAR-T15200-50mg50mg£2,464.00
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TAR-T15200-100mg100mg£3,283.00
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This product comes from: United States.
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Further Information

Bioactivity:
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
CAS:
174402-32-5
Formula:
C29H28N4O11
Molecular Weight:
608.56
Pathway:
DNA Damage/DNA Repair
Purity:
0.98
SMILES:
OCC(CO)NN1C(=O)c2c(C1=O)c1c3ccc(O)cc3n([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c1c1[nH]c3cc(O)ccc3c21
Target:
Topoisomerase

References

1. Saif MW, et al. Edotecarin: a novel topoisomerase I inhibitor. Clin Colorectal Cancer. 2005 May;5(1):27-36. 2. Ciomei M, et al. Antitumor efficacy of edotecarin as a single agent and in combination with chemotherapy agents in a xenograft model. Clin Cancer Res. 2006 May 1;12(9):2856-61.