TargetMol

Ertugliflozin L-pyroglutamic acid

Product Code:
 
TAR-T15244
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15244-5mg5mg£102.00
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TAR-T15244-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T15244-10mg10mg£115.00
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TAR-T15244-25mg25mg£136.00
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TAR-T15244-50mg50mg£148.00
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TAR-T15244-100mg100mg£185.00
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TAR-T15244-200mg200mg£241.00
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TAR-T15244-500mg500mg£358.00
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Further Information

Bioactivity:
Ertugliflozin L-pyroglutamic acid is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM. Ertugliflozin L-pyroglutamic acid can be used for studies about the treatment of type 2 diabetes mellitus.
CAS:
1210344-83-4
Formula:
C27H32ClNO10
Molecular Weight:
566
Pathway:
GPCR/G Protein;
Purity:
0.98
SMILES:
OC(=O)[C@@H]1CCC(=O)N1.CCOc1ccc(Cc2cc(ccc2Cl)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1
Target:
SGLT

References

1. Miao Z, et al. Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects. Drug Metab Dispos. 2013 Feb;41(2):445-56. 2. Kalgutkar AS, et al. Preclinical species and human disposition of PF-04971729, a selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus. Drug Metab Dispos. 2011 Sep;39(9):1609-19. 3. Mascitti V, et al. Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors. J Med Chem. 2011 Apr 28;54(8):2952-60.