TargetMol

Exicorilant

Product Code:
 
TAR-T15264
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15264-5mg5mg£1,492.00
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TAR-T15264-50mg50mg£2,946.00
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Quantity:
TAR-T15264-100mg100mg£4,006.00
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This product comes from: United States.
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Further Information

Bioactivity:
Exicorilant is a selective and oral active glucocorticoid receptor (GR) antagonist (Ki: 7 nM) and it also has the potential to overcome adiposity, glucose intolerance, and dyslipidemia.
CAS:
1781244-77-6
Formula:
C26H23F4N7O3S
Molecular Weight:
589.57
Purity:
0.98
SMILES:
[H][C@@]12CCN(C[C@]1(Cc1cnn(c1C2)-c1ccc(F)cc1)C(=O)c1cc(ccn1)C(F)(F)F)S(=O)(=O)c1cnn(C)n1

References

1. Hunt HJ, et al. Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist. J Med Chem. 2017 Apr 27;60(8):3405-3421. 2. Kroon J, et al. Selective Glucocorticoid Receptor Antagonist CORT125281 Activates Brown Adipose Tissue and Alters Lipid Distribution in Male Mice. Endocrinology. 2018 Jan 1;159(1):535-546.