TargetMol

Glesatinib

Product Code:
 
TAR-T15384
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15384-5mg5mg£930.00
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TAR-T15384-50mg50mg£1,821.00
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TAR-T15384-100mg100mg£2,319.00
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This product comes from: United States.
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Further Information

Bioactivity:
Glesatinib is an orally active and potent dual inhibitor of MET/SMO. Glesatinib is also a tyrosine kinase inhibitor. It antagonizes P-glycoprotein mediated multidrug resistance (MDR) in NSCLC.
CAS:
936694-12-1
Formula:
C31H27F2N5O3S2
Molecular Weight:
619.71
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
COCCNCc1ccc(nc1)-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccc(F)cc4)cc3F)c2s1
Target:
c-Met/HGFR

References

1. Morgillo F, et al. Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer. J Med Chem. 2017 Sep 14;60(17):7447-7458. 2. Cui Q, et al. Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated MultidrugResistance in Cancer Cells. Front Oncol. 2019 Apr 25;9:313.