TargetMol

GNE-207

Product Code:
 
TAR-T15399
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15399-5mg5mg£724.00
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TAR-T15399-50mg50mg£2,303.00
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TAR-T15399-100mg100mg£3,042.00
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Further Information

Bioactivity:
GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expression in MV-4-11 cells).
CAS:
2158266-58-9
Formula:
C29H30N6O3
Molecular Weight:
510.598
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
CNC(=O)c1ccc(cn1)-c1cc2cccc(-c3nn(C4CCOCC4)c4CCN(Cc34)C(C)=O)c2cn1
Target:
Epigenetic Reader Domain

References

1. Lai KW, et al. Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300. ioorg Med Chem Lett. 2018 Jan 1;28(1):15-23.