TargetMol

GSK256073

Product Code:
 
TAR-T15432
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15432-1mg1mg£128.00
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TAR-T15432-2mg2mg£149.00
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TAR-T15432-5mg5mg£204.00
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TAR-T15432-1mL1 mL * 10 mM (in DMSO)£217.00
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TAR-T15432-10mg10mg£284.00
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TAR-T15432-25mg25mg£444.00
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TAR-T15432-50mg50mg£618.00
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TAR-T15432-100mg100mg£849.00
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This product comes from: United States.
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Further Information

Bioactivity:
GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist (pEC50: 7.5). GSK256073 acutely improves glucose homeostasis via inhibition of lipolysis.
CAS:
862892-90-8
Formula:
C10H13ClN4O2
Molecular Weight:
256.69
Pathway:
; GPCR/G Protein; Endocrinology/Hormones
Purity:
0.9803
SMILES:
CCCCCn1c2nc(Cl)[nH]c2c(=O)[nH]c1=O
Target:
GPR;

References

1. Dobbins RL, et al. GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus.Diabetes Obes Metab.?2013 Nov;15(11):1013-21. 2. Sprecher D, et al. Discovery and characterization of GSK256073, a non-flushing hydroxy-carboxylic acid receptor 2 (HCA2) agonist.Eur J Pharmacol. 2015 Jun 5;756:1-7.