TargetMol

IK1 inhibitor PA-6

Product Code:
 
TAR-T15555
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15555-2mg2mg£98.00
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TAR-T15555-5mg5mg£114.00
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TAR-T15555-1mL1 mL * 10 mM (in DMSO)£119.00
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TAR-T15555-10mg10mg£155.00
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TAR-T15555-25mg25mg£230.00
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TAR-T15555-50mg50mg£340.00
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TAR-T15555-100mg100mg£466.00
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Further Information

Bioactivity:
IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouse KIR2.x currents).
CAS:
500715-03-7
Formula:
C31H32N4O2
Molecular Weight:
492.623
Pathway:
Membrane transporter/Ion channel
Purity:
0.9877
SMILES:
N=C(Nc1ccc(OCCCCCOc2ccc(NC(=N)c3ccccc3)cc2)cc1)c1ccccc1
Target:
Potassium Channel

References

1. Ji Y, et al. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. Br J Pharmacol. 2017 Aug;174(15):2576-2590. 2. Ji Y, et al. PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression. J Biomed Sci. 2017 Jul 15;24(1):44.