TargetMol

K-252b

Product Code:
 
TAR-T15637
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15637-5mg5mg£1,177.00
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Further Information

Bioactivity:
K-252b is an indolocarbazole isolated from the actinomycete Nocardiopsis and is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in culture because it can?t pass through the cell membrane freely.
CAS:
99570-78-2
Formula:
C26H19N3O5
Molecular Weight:
453.454
Pathway:
Cytoskeletal Signaling; Chromatin/Epigenetic
Purity:
0.98
SMILES:
[H][C@]12C[C@](O)(C(O)=O)[C@](C)(O1)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Target:
PKC

References

1. Yasuzawa, T., et al. The structures of the novel protein kinase C inhibitors K-252a, b, c AND d Journal of Antibiotics 39(8), 1072-1078 (1986). 2. Plomp, J.J., et al. Involvement of protein kinases in the upregulation of acetylcholine release at endplates of ?-bungarotoxin-treated rats Journal of Physiology 493, 175-186 (1996). 3. Zhu, X., et al. Evidence of ectokinase-mediated phosphorylation of osteopontin and bone sialoprotein by osteoblasts during bone formation in vitro Biochemistry Journal 323, 637-643 (1997).