TargetMol

KAG-308

Product Code:
 
TAR-T15642
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP2, EP3, and IP receptor. KAG-308 suppresses colitis and promotes histological mucosal healing, which potently inhibits TNF-α production.
CAS:
1215192-68-9
Formula:
C24H30F2N4O3
Molecular Weight:
460.526
Pathway:
GPCR/G Protein; Immunology/Inflammation
Purity:
0.98
SMILES:
[H][C@]12C[C@@H](O)[C@H](C=C[C@@H](O)[C@H](C)c3cccc(C)c3)[C@@]1([H])C(F)(F)C(O2)=CCCCc1nnn[nH]1
Target:
Prostaglandin Receptor

References

1. Watanabe Y, et al. KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration. Eur J Pharmacol. 2015 May 5;754:179-89.