TargetMol

L-741626

Product Code:
 
TAR-T15686
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15686-5mg5mg£108.00
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Quantity:
TAR-T15686-1mL1 mL * 10 mM (in DMSO)£112.00
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TAR-T15686-10mg10mg£135.00
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TAR-T15686-25mg25mg£196.00
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TAR-T15686-50mg50mg£303.00
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Quantity:
TAR-T15686-100mg100mg£442.00
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Further Information

Bioactivity:
L-741626 is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively).
CAS:
81226-60-0
Formula:
C20H21ClN2O
Molecular Weight:
340.85
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.989
SMILES:
OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)cc1
Target:
Dopamine Receptor

References

1. Lewitus GM, et al. Microglial TNF-? Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization. Neuron. 2016 May 4;90(3):483-91. 2. Grundt P, et al. Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR. Bioorg Med Chem Lett. 2007 Feb 1;17(3):745-9. 3. Koffarnus MN, et al. The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats. Psychopharmacology (Berl). 2009 Apr;203(2):317-27. 4. Kulagowski JJ, et al. 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem. 1996 May 10;39(10):1941-2.