TargetMol

Nanaomycin A

Product Code:
 
TAR-T16269
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16269-5mg5mg£1,619.00
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Further Information

Bioactivity:
Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).
CAS:
52934-83-5
Formula:
C16H14O6
Molecular Weight:
302.282
Pathway:
Metabolism; Chromatin/Epigenetic; Microbiology/Virology
Purity:
0.98
SMILES:
C[C@@H]1O[C@@H](CC(O)=O)CC2=C1C(=O)c1c(O)cccc1C2=O
Target:
DNA Methyltransferase; Dehydrogenase; Parasite

References

1. Kuck D, et al.Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells.Mol Cancer Ther. 2010 Nov;9(11):3015-23. 2. Tanaka Y, et al.Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol.J Antibiot (Tokyo). 1999 Oct;52(10):880-8.