Nigericin

Product Code:

TAR-T16323

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

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Code	Size	Price

TAR-T16323-5mg

5mg

£850.00

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Further Information

Bioactivity:

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that acts as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin can be an NLRP3 activator that causes the release of IL-1β as a NALP3-dependent manner. Nigericin induces eryptosis, an effect paralleled by ROS formation, and in part due to the induction of oxidative stress. Nigericin causes apoptosis.

CAS:

28380-24-7

Formula:

C40H68O11

Molecular Weight:

724.973

Purity:

0.98

SMILES:

[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]1(C)CC[C@@]([H])(O1)[C@]1(C)C[C@@H](C)[C@]2(O1)O[C@]([H])(C[C@@]1([H])CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C(O)=O)C[C@@H](OC)[C@H]2C)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C

Documents

References

1. Zotova L, et al. Novel components of an active mitochondrial K(+)/H(+) exchange. J Biol Chem. 2010 May 7;285(19):14399-414. 2. Mariathasan S, et al.Cryopyrin activates the inflammasome in response to toxins and ATP.Nature. 2006 Mar 9;440(7081):228-32. 3. Bissinger R, et al. Triggering of Suicidal Erythrocyte Death by the Antibiotic Ionophore Nigericin. Basic Clin Pharmacol Toxicol. 2016 May;118(5):381-9. 4. Gao M, Qin Y, Li A, et al. Calibration and measurement of mitochondrial pH in intact adult rat cardiomyocytes[J]. STAR Protocols. 2021, 2(2): 100543.