TargetMol

PAT-048

Product Code:
 
TAR-T16434
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16434-5mg5mg£930.00
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TAR-T16434-50mg50mg£1,821.00
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TAR-T16434-100mg100mg£2,319.00
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Further Information

Bioactivity:
PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in the lung fibrosis model. PAT-048 has an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma.
CAS:
1359983-15-5
Formula:
C22H18ClF2N3O2S
Molecular Weight:
461.91
Pathway:
Metabolism
Purity:
0.98
SMILES:
CCCn1cc(cn1)-n1c(C)c(Sc2cccc(C(O)=O)c2F)c2ccc(Cl)c(F)c12
Target:
PDE

References

1. Castelino FV, et al. An Autotaxin/Lysophosphatidic Acid/Interleukin-6 Amplification Loop Drives Scleroderma Fibrosis. Arthritis Rheumatol. 2016 Dec;68(12):2964-2974. 2. Black KE, et al. Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis. FASEB J. 2016 Jun;30(6):2435-50.