TargetMol

PF-04995274

Product Code:
 
TAR-T16481
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16481-1mg1mg£95.00
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TAR-T16481-1mL1 mL * 10 mM (in DMSO)£124.00
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TAR-T16481-5mg5mg£125.00
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TAR-T16481-10mg10mg£172.00
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TAR-T16481-25mg25mg£237.00
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TAR-T16481-50mg50mg£367.00
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TAR-T16481-100mg100mg£497.00
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Further Information

Bioactivity:
PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has an EC50 range of 0.26-0.47 nM for human 5-HT4A/4B/4D/4E (Ki range of 0.15-0.46 nM). It also has an EC50 range of 0.59-0.65 nM for rat 5-HT4S/4L/4E (Ki of 0.30 nM for rat 5-HT4S).
CAS:
1331782-27-4
Formula:
C23H32N2O6
Molecular Weight:
432.517
Pathway:
Neuroscience; GPCR/G Protein
Purity:
0.9955
SMILES:
OC1(CN2CCC(COc3noc4cccc(O[C@@H]5CCOC5)c34)CC2)CCOCC1
Target:
5-HT Receptor

References

1. Chen BK, et al. Prophylactic efficacy of 5-HT4R agonists against stress. Neuropsychopharmacology. 2019 Oct 10. 2. Grimwood S, et al. Translational receptor occupancy for the 5-HT4 partial agonist PF-04995274 in rats, non-human primates and healthy volunteers. Alzheimer?s Dement: J Alzheimer?s Assoc. 2011;7:S653. 3. Timothy Nicholas1, et al. Systems pharmacology modeling in neuroscience: Prediction and outcome of PF-04995274, a 5-HT4 partial agonist, in a clinical scopolamine impairment trial. Advances in Alzheimer's Disease. Vol.2 No.3(2013).