TargetMol

PF-3450074

Product Code:
 
TAR-T16500
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16500-5mg5mg£105.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T16500-1mL1 mL * 10 mM (in DMSO)£109.00
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Quantity:
TAR-T16500-10mg10mg£134.00
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Quantity:
TAR-T16500-25mg25mg£177.00
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Quantity:
TAR-T16500-50mg50mg£252.00
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Quantity:
TAR-T16500-100mg100mg£389.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
PF-3450074 acts at an early stage of HIV-1 infection inhibits viral replication by directly competing with the binding of CPSF6 (nuclear host factors cleavage and polyadenylation specific factor 6) and NUP153 (nucleoporin 153), and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. PF-3450074 is a specifical inhibitor of?HIV-1 capsid protein (CA) and shows a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM).
CAS:
1352879-65-2
Formula:
C27H27N3O2
Molecular Weight:
425.52
Pathway:
Proteases/Proteasome; Microbiology/Virology
Purity:
0.9992
SMILES:
O=C(N[C@@H](CC1=CC=CC=C1)C(N(C)C2=CC=CC=C2)=O)CC3=C(C)NC4=C3C=CC=C4
Target:
HIV Protease

References

1. Xu JP, et al. Exploring?Modifications?of an?HIV-1?Capsid?Inhibitor:?Design,?Synthesis, and?Mechanism?of?Action.J Drug Des Res.?2018;5(2). pii: 1070. Epub 2018 Aug 13. 2. Shi J, et al. Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization.J Virol. 2011 Jan;85(1):542-9.