TargetMol

PF-5006739

Product Code:
 
TAR-T16507
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity. PF-5006739 decreases opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner.
CAS:
1293395-67-1
Formula:
C22H22FN7O
Molecular Weight:
419.464
Pathway:
Metabolism; Stem Cells
Purity:
0.98
SMILES:
Nc1nccc(n1)-c1c(ncn1C1CCN(Cc2ccon2)CC1)-c1ccc(F)cc1
Target:
Casein Kinase

References

1. Wager TT, et al. Casein kinase 1?/? inhibitor PF-5006739 attenuates opioid drug-seeking behavior. ACS Chem Neurosci. 2014 Dec 17;5(12):1253-65. 2. Cunningham PS, et al. Targeting of the circadian clock via CK1?/? to improve glucose homeostasis in obesity.Sci Rep. 2016 Jul 21;6:29983.