TargetMol

Ambrisentan

Product Code:
 
TAR-T1655
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1655-5mg5mg£111.00
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TAR-T1655-1mL1 mL * 10 mM (in DMSO)£117.00
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TAR-T1655-10mg10mg£121.00
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TAR-T1655-25mg25mg£164.00
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TAR-T1655-50mg50mg£213.00
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TAR-T1655-100mg100mg£283.00
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TAR-T1655-500mg500mg£598.00
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Further Information

Bioactivity:
Ambrisentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but has yet to be implicated in cases of clinically apparent acute liver injury.
CAS:
177036-94-1
Formula:
C22H22N2O4
Molecular Weight:
378.42
Pathway:
GPCR/G Protein
Purity:
0.9985
SMILES:
COC([C@H](Oc1nc(C)cc(C)n1)C(O)=O)(c1ccccc1)c1ccccc1
Target:
Endothelin Receptor

References

1. Weiss J, et al. Eur J Pharmacol,2011, 660(2-3), 298-304. 2. Yokoyama Y, et al. Biol Pharm Bull,2014, 37(3), 461-465. 3. Weiss J, et al. Biochem Pharmacol,2013, 85(2), 265-273. 4. Osano A, et al. J Pharmacol Sci,2014, 124(1), 86-91. 5. Buckley MS, et al. Expert Opin Drug Metab Toxicol,2011, 7(3), 371-380. 6. Okamoto T, et al. Antifibrotic effects of Ambrisentan, an endothelin-A receptor antagonist, in a non-alcoholic steatohepatitis mouse model. World J Hepatol. 2016 Aug 8;8(22):933-41.