TargetMol

PS315

Product Code:
 
TAR-T16671
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16671-5mg5mg£850.00
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Quantity:
TAR-T16671-50mg50mg£1,661.00
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Quantity:
TAR-T16671-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKC? (IC50=30 μM). PS315 has anti-cancer activity. PS315 is a derivative of PS48 and is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing displacement of the active site residue Lys111.
CAS:
1221964-50-6
Formula:
C23H19ClO2
Molecular Weight:
362.85
Pathway:
Cytoskeletal Signaling; Chromatin/Epigenetic
Purity:
0.98
SMILES:
OC(=O)C=C(CCc1ccc(Cl)cc1)c1ccc(cc1)-c1ccccc1
Target:
PKC

References

1. Zhang H, et al. Molecular mechanism of regulation of the atypical protein kinase C by N-terminal domains and an allosteric small compound. Chem Biol. 2014 Jun 19;21(6):754-65.