TargetMol

Pyr6

Product Code:
 
TAR-T16688
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16688-2mg2mg£97.00
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TAR-T16688-5mg5mg£112.00
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TAR-T16688-1mL1 mL * 10 mM (in DMSO)£117.00
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TAR-T16688-10mg10mg£140.00
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TAR-T16688-25mg25mg£185.00
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TAR-T16688-50mg50mg£242.00
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TAR-T16688-100mg100mg£327.00
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Further Information

Bioactivity:
Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.
CAS:
245747-08-4
Formula:
C17H9F7N4O
Molecular Weight:
418.275
Pathway:
Membrane transporter/Ion channel
Purity:
0.9918
SMILES:
Fc1cnccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C(F)(F)F)C(F)(F)F
Target:
TRP/TRPV Channel

References

1. Schleifer H, et al. Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways. Br J Pharmacol. 2012 Dec;167(8):1712-22.