TargetMol

Ralimetinib

Product Code:
 
TAR-T16721
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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CodeSizePrice
TAR-T16721-5mg5mg£850.00
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TAR-T16721-50mg50mg£1,661.00
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TAR-T16721-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Ralimetinib selectively inhibits phosphorylation of MK2 (Thr334) and has no effect on phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc. Ralimetinib is an effective and selective, ATP-competitive inhibitor of p38 MAPK α/β (IC50s: 5.3 and 3.2 nM, respectively).
CAS:
862505-00-8
Formula:
C24H29FN6
Molecular Weight:
420.536
Purity:
0.98
SMILES:
CC(C)(C)Cn1c(N)nc2ccc(nc12)-c1[nH]c(nc1-c1ccc(F)cc1)C(C)(C)C

References

1. Campbell RM, et al. Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity. Mol Cancer Ther. 2014 Feb;13(2):364-74.