TargetMol

RO-5963

Product Code:
 
TAR-T16771
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16771-1mg1mg£213.00
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TAR-T16771-5mg5mg£535.00
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TAR-T16771-1mL1 mL * 10 mM (in DMSO)£595.00
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TAR-T16771-10mg10mg£740.00
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TAR-T16771-25mg25mg£1,091.00
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TAR-T16771-50mg50mg£1,428.00
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TAR-T16771-100mg100mg£1,910.00
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TAR-T16771-500mg500mg£3,781.00
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Further Information

Bioactivity:
RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).
CAS:
1416663-77-8
Formula:
C24H21ClF2N4O5
Molecular Weight:
518.9
Pathway:
Apoptosis
Purity:
0.98
SMILES:
Cc1c(Cl)ccc2c(C=C3NC(=O)N(C(C(=O)NC(CO)CO)c4ccc(F)c(F)c4)C3=O)c[nH]c12
Target:
Mdm2

References

1. Graves B, et al. Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11788-93.