TargetMol

Rodatristat ethyl

Product Code:
 
TAR-T16779
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16779-5mg5mg£684.00
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TAR-T16779-50mg50mg£2,464.00
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TAR-T16779-100mg100mg£3,283.00
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Further Information

Bioactivity:
Rodatristat ethyl decreases the level of 5-HT and significantly reduces pulmonary arterial hypertension. Rodatristat ethyl is a first-in-class oral tryptophan hydroxylase 1 Inhibitor.
CAS:
1673571-51-1
Formula:
C29H31ClF3N5O3
Molecular Weight:
590.04
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.98
SMILES:
CCOC(=O)[C@@H]1CC2(CN1)CCN(CC2)c1cc(O[C@H](c2ccc(Cl)cc2-c2ccccc2)C(F)(F)F)nc(N)n1
Target:
5-HT Receptor

References

1. Aiello RJ, et al. Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Modelsof Pulmonary Hypertension. J Pharmacol Exp Ther. 2017 Feb;360(2):267-279. 2. Alice Mel?o, MSc. Early Results on Rodatristat Ethyl Support Launch of Phase 2 Trial in PAH Patients. FEBRUARY 4, 2019.