TargetMol

RO 4938581

Product Code:
 
TAR-T16794
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16794-5mg5mg£304.00
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TAR-T16794-50mg50mg£1,364.00
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TAR-T16794-100mg100mg£2,199.00
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Further Information

Bioactivity:
RO 4938581 is an effective and selective agonist of GABAA α5 inverse (Ki: 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively)).
CAS:
883093-10-5
Formula:
C13H8BrF2N5
Molecular Weight:
352.143
Pathway:
Membrane transporter/Ion channel; Neuroscience
Purity:
0.98
SMILES:
FC(F)c1ncn-2c1Cn1ncnc1-c1cc(Br)ccc-21
Target:
GABA Receptor

References

1. Knust H, et al. The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4.