TargetMol

Sampatrilat

Product Code:
 
TAR-T16840
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16840-5mg5mg£511.00
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TAR-T16840-50mg50mg£1,982.00
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Quantity:
TAR-T16840-100mg100mg£2,560.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Sampatrilat is an effecive and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase. Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM).
CAS:
129981-36-8
Formula:
C26H40N4O9S
Molecular Weight:
584.69
Purity:
0.98
SMILES:
CS(=O)(=O)N[C@@H](CCCCN)C(=O)NC[C@H](CC1(CCCC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)C(O)=O

References

1. Sharma RK, et al. The Dynamic Nonprime Binding of Sampatrilat to the C-Domain of Angiotensin-Converting Enzyme. J Chem Inf Model.?2016 Dec 27;56(12):2486-2494. 2. Maki T, et al. Beneficial effects of sampatrilat, a novel vasopeptidase inhibitor, on cardiac remodeling and function of rats with chronic heart failure following left coronary artery ligation.J Pharmacol Exp Ther.?2003 Apr;305(1):97-105.